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ceramide synthesis inhibitors  (Croda International Plc)

 
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    Croda International Plc ceramide synthesis inhibitors
    Ceramide Synthesis Inhibitors, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 98/100, based on 1378 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ceramide+synthesis+inhibitors/Ceramide/pm41325527-434-24-62
    Average 98 stars, based on 1378 article reviews
    ceramide synthesis inhibitors - by Bioz Stars, 2026-10
    98/100 stars

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    Modification:

    Article Title: Tppp3 determines basal body positioning and identity of respiratory cilia via microtubule assembly and sphingolipid homeostasis.
    Article Snippet: .. The whole trachea tissue was immediately subjected to air–liquid interface (ALI) culture (23) at 37 °C in a medium containing ceramide or ceramide and ceramide synthesis inhibitors under 5% CO2 for 18 h. The culture medium consisted of Dulbecco’s Modified Eagle Medium supplemented with 25 mM 4- (2- hydroxyethyl)piperazine- 1- ethanesulfonic acid, 2% Fetal Bovine Serum, and 1 μM C24:1 ceramide (d18:1/24:1(15Z)) (Avanti, 860525P). ..



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    ERBB2-positive cells' sensitivity to palmitate is through ROS formation and <t>ceramide</t> production. (a) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0, 0.5, and 1 μmol/l of N -acetyl-cysteine (NAC) for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. *** P < 0.05. (b) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0 and 10 μmol/l of the ceramide synthesis inhibitor <t>fumonisin</t> <t>B1</t> for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. ROS, reactive oxygen species.
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    ERBB2-positive cells' sensitivity to palmitate is through ROS formation and <t>ceramide</t> production. (a) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0, 0.5, and 1 μmol/l of N -acetyl-cysteine (NAC) for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. *** P < 0.05. (b) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0 and 10 μmol/l of the ceramide synthesis inhibitor <t>fumonisin</t> <t>B1</t> for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. ROS, reactive oxygen species.
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    ERBB2-positive cells' sensitivity to palmitate is through ROS formation and <t>ceramide</t> production. (a) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0, 0.5, and 1 μmol/l of N -acetyl-cysteine (NAC) for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. *** P < 0.05. (b) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0 and 10 μmol/l of the ceramide synthesis inhibitor <t>fumonisin</t> <t>B1</t> for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. ROS, reactive oxygen species.
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    ERBB2-positive cells' sensitivity to palmitate is through ROS formation and ceramide production. (a) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0, 0.5, and 1 μmol/l of N -acetyl-cysteine (NAC) for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. *** P < 0.05. (b) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0 and 10 μmol/l of the ceramide synthesis inhibitor fumonisin B1 for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. ROS, reactive oxygen species.

    Journal: Breast Cancer Research : BCR

    Article Title: Peroxisome proliferator-activated receptor-γ protects ERBB2-positive breast cancer cells from palmitate toxicity

    doi: 10.1186/bcr2240

    Figure Lengend Snippet: ERBB2-positive cells' sensitivity to palmitate is through ROS formation and ceramide production. (a) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0, 0.5, and 1 μmol/l of N -acetyl-cysteine (NAC) for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. *** P < 0.05. (b) BT474 and MDA-MB-361 cells were treated with vehicle or 20 μmol/l GW9662 together with 0 and 10 μmol/l of the ceramide synthesis inhibitor fumonisin B1 for 72 hours. Live cells were counted and presented as percentage of the GW9662 control. Error bars indicate the standard deviation from three individual experiments. ROS, reactive oxygen species.

    Article Snippet: The PPARγ antagonist GW9662, the fatty acid palmitate, and the ceramide synthesis inhibitor fumonisin B1 were obtained from Sigma-Aldrich (St. Louis, MO, USA).

    Techniques: Standard Deviation